みやこめっせにて開催されます日本薬物動態学会第40回年会に出展いたします。ランチョンセミナー並びにポスターの展示を行いますので、お気軽にお立ち寄りください。海外の技術者も多数参加いたします。皆様のお越しを心よりお待ちしております。
日本薬物動態学会（JSSX）第40回年会ウェブサイト：
https://jssx40.org/
WuXi AppTec Japan ブース：31
ランチョンセミナー：
演題 「核酸ならびにペプチド医薬のインビトロ薬物代謝とタンパク結合の最前線」
In Vitro Drug Metabolism and Protein Binding of Oligonucleotide and Peptide: Advances and Capabilities
演者 Jie Wang（Associate Director / Principal Scientist）
日時 10月22日（水）11:20-12:20
場所 C会場（Room C）
要旨 In vitro metabolic stability and protein binding studies are crucial for optimizing oligonucleotide and peptide drugs, as they significantly impact drug delivery, distribution, retention, and safety. However, inconsistencies in siRNA drug binding results have been reported due to varying plasma protein binding (PPB) assay methods. This presentation will introduce various systems used for studying the metabolic stability of oligonucleotides and their applicability. It will also cover different techniques for protein binding studies, highlighting their characteristics, challenges, and discrepancies. We will discuss the reasons behind inconsistent PPB findings for siRNAs and aim to improve the reliability of PPB assessments in oligonucleotide drug development, potentially influencing future research methodologies. Additionally, the presentation will address challenges in peptide development, PPB determination, and the role of PPB in predicting peptide half-lives.
ポスター発表：
BP-20: Rapid screening and characterization of payload-related catabolites derived from ADCs in in vitro model by high-resolution mass spectrometry
BP-21: In vitro platform for assessing ADC stability and payload release
P-5: Establish a high-throughput exposed polar surface area (EPSA) screening platform
P-48: Establishment of an in vitro screening system for human pregnane X receptor (PXR) agonists
P-108: A novel and accurate method for assessing the stability of maleimide-containing linker-payloads in the β-glucuronidase stability assay
P-118: Optimization and assessment of intrathecal (IT) administration to improve drug delivery to the CNS in rats